CannaTrials adheres to evidence-based medicine – making statements based on medical evidence.

This page is excerpted and quoted from the National Academies of Science, Engineering, and Medicine.    A Committee of over 40 experts, researchers, and reviewers in The Health and Medicine Division published a 486 page report in 2017 entitled “The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research.
If you would like to access the entire report you may do so by clicking this link.

Medical Marijuana and Acute Myocardial Infarction

“Each year, an estimated approximately 550,000 Americans have an incident (i.e., first-time) heart attack (acute myocardial infarction, or AMI) and about 200,000 have a recurrent attack (Mozaffarian et al., 2016). Of those who have a heart attack each year, about 116,000 die as a result of their coronary event (Mozaffarian et al., 2016). The committee responsible for the IOM report Marijuana and Medicine: Assessing the Science Base (1999) did not make any conclusions or recommendations regarding cannabis use and acute myocardial infarctions.

The acute cardiovascular effects of cannabis include increases in heart rate and supine blood pressure and postural hypotension (Beaconsfield et al., 1972; Benowitz and Jones, 1981). Smoking cannabis decreases exercise test duration on maximal exercise tests and increases the heart rate at submaximal levels of exercise (Renaud and Cormier, 1986). These acute effects provide a physiological basis for cardiac ischemia to develop in cannabis users. In fact, the time from exercise to the onset of angina pectoris is decreased by smoking one cannabis cigarette (Aronow and Cassidy, 1974). Tolerance develops to the acute effects of tetrahydrocannabinol (THC) over several days to a few weeks (Gorelick et al., 2013). Reported cardiovascular effects that may increase the risk of AMI include irregular heart rate (Khiabani et al., 2008) and impaired vascular endothelial function (demonstrated in rates from exposure to secondhand cannabis smoke) (Wang et al., 2016). Additionally, carbon dioxide production from smoked cannabis decreases the oxygen-carrying capacity of the blood and may contribute to the development of cardiac ischemia.

There have been numerous case reports suggesting that cannabis use is associated with the occurrence of AMI. The two primary studies that have quantified the risk of AMI associated with cannabis use and that were rated as good or fair are reviewed below.

While there are a number of reports of an association between cannabis use and AMI, only the two studies described above quantify risk, with the Sidney (2002) study demonstrating no association with an increased or decreased risk of AMI and the Mittleman et al. (2001) study finding that cannabis use may act as a trigger for AMI. The limitations of these studies were described. More generally, with the Mittleman study as an exception, most reports of adverse cardiovascular effects of cannabis, including AMI, have been conducted in a relatively young age range, while major cardiovascular events are concentrated in older adults and the findings may not be generalizable to this age group. Other general limitations beyond those already mentioned in the description of the studies include the absence of the impact of the route of consumption (e.g, smoked, edible, etc.); dose, including accounting for the content of THC and other cannabinoids and potential additives or contaminants; and total lifetime duration/dose of cannabis use. Overall, the articles were judged to be of fair quality for assessing the risk of acute myocardial infarction associated with cannabis use.

The role of cannabis as a trigger of AMI is plausible, given its cardiostimulatory effects, which may cause ischemia in susceptible hearts. Carboxyhemoglobinemia from combustion of cannabis resulting in a decreased oxygen-carrying capacity of blood may also contribute to ischemia. Given the physiologic plausibility for a trigger effect, smoking cannabis may put individuals, particularly those at high risk for cardiovascular disease, at increased risk for AMI.

CONCLUSION 6-1
6-1(a) There is limited evidence of a statistical association between cannabis smoking and the triggering of acute myocardial infarction. 
6-1(b) There is no evidence to support or refute a statistical association between chronic effects of cannabis use and the risk of acute myocardial infarction.[1]

[1] The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research | The National Academies Press. 2017. Pages 163-166. Download the complete 486 page report.

**Important Note:  On many of the health conditions studied by NAS, there was no conclusive evidence of cannabis effectiveness from the study results they reviewed.  The authors included a long section on “research gaps.

It is the Vision and Mission of CannaTrials to fill in some of these research gaps with cannabis clinical trials using specific medical marijuana formulations and testing them in a research protocol with local patients, physicians, processors and dispensaries.  If you are interested in participating in a clinical trial, and helping improve scientific knowledge about health effects of cannabis, please click one of the buttons below on this page.

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